Depressive symptoms and neurotrophin levels in ostomy patients

ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients.

摘要
目的：本研究旨在对比造口术患者与健康对照组，探讨其外周血清中抑郁症状、神经营养因子（BDNF、NGF、NT-3）及皮质醇水平的变化。
方法：本研究共纳入29例造口术患者及30例健康对照者。采用酶联免疫吸附测定（ELISA）检测外周血清中的脑源性神经营养因子（BDNF）、神经生长因子（NGF）、神经营养因子3（NT-3）及皮质醇水平。抑郁症状采用汉密尔顿抑郁量表（HDRS）评定，重性抑郁障碍的诊断基于临床访谈，并经《DSM-IV轴I障碍结构化临床访谈》（SCID-I）确认。
结果：结果显示，与健康对照组相比，造口术患者外周血清中的脑源性神经营养因子（BDNF）水平显著降低，神经营养因子3（NT-3）水平显著升高；神经生长因子（NGF）及皮质醇水平在两组间无显著差异。汉密尔顿抑郁量表（HDRS）评定结果显示，造口术患者的抑郁症状评分显著高于健康对照组。而经SCID-I确诊的重性抑郁障碍在两组间无显著差异。
结论：本研究结果提示，造口术可引发显著的抑郁症状，并导致患者外周血清样本中的神经营养因子水平发生异常改变。