Identification of LncRNA Expression Signatures for breast cancer brain metastasis (BCBM)

To identify BCBM-relevant lncRNAs, we assessed the expression profiles of lncRNAs in parental MDA-MB-231 (231-PAR) cells and isogenic brain metastatic cells (231-BRN), which were isolated from brain-seeking 231-PAR cells LncRNA Expression profiling analysis of the 231-PAR and 231-BRN by Arraystar Human LncRNA Array v3.0.

为鉴定与乳腺癌脑转移（BCBM）相关的长链非编码RNA（long non-coding RNAs，lncRNAs），我们对亲本MDA-MB-231（231-PAR）细胞及同基因脑转移细胞（231-BRN）的lncRNAs表达谱进行了分析；其中231-BRN细胞系由经脑靶向筛选的231-PAR细胞分离得到。本研究采用Arraystar人类长链非编码RNA芯片v3.0，完成了231-PAR与231-BRN细胞的lncRNAs表达谱分析。