Dynamic 3D X-ray micro-CT data of a tablet dissolution in a water-based gel

<strong>Summary</strong> This submission contains a dynamic tomographic X-ray data of a tablet dissolving in a water-based gel. The data is collected over a 5-minute period during which the sample is rotated rapidly as effervescent bubbles are formed and travelling to the surface of the gel. The data is made available as part of Case Study 3 in [Coban 2020]. <strong>Apparatus</strong> The dataset is acquired using the custom-built and highly flexible CT scanner, FleX-ray Laboratory, developed by TESCAN-XRE, located at CWI in Amsterdam. This apparatus consists of a cone-beam microfocus X-ray point source that projects polychromatic X-rays onto a 1944-by-1536 pixels, 14-bit, flat detector panel. Full details can be found in [Coban 2020]. <strong>Sample Information</strong> The setup consists of a store-bought denture cleaning tablet, placed at the bottom of a clear cylindrical plastic container. These tablets are typically designed to be fast-dissolving, and produce small and compact channels of bubbles. We use a denture cleaning tablet in particular as the dissolution time in water varies from 3 to 5 minutes, meaning the bubbles are produced at a slower rate. In addition, we use a store-bought water-based gel instead of water to slow down the bubble displacement during the experiment. <strong>Experimental Plan</strong> This experiment is performed such that 120 projections are collected over 360 degrees, for a total of 83 rotations, with exposure time 30 ms for each projection. This means that in total the submission contains 10000 projections. This took a total of 5 minutes of acquisition time, during which the tablet moved due to saturation but did not completely dissolve. The spatial resolution is 95μm, and the field of view was cropped to the boundaries of the sample holder (each projection image is of size 647px×768px). Our experimental setup allowed the collection of open and closed shutter (flat- and dark-field) images before decanting the gel onto the tablet. No centrifugal force effect was observed on the bubbles travelling during the scan or in our test runs at the given rotational speed. All raw data (i.e. no corrections) is made available in .tif format. <strong>List of Contents</strong> The contents of the submission is given below. <strong>scan</strong>: A 5-minute dynamic CT data folder containing dark-field (or closed-shutter) image, <em>di000000.tif,</em> pre flat-field (or open-shutter before acquisition) image, <em>io000000.tif</em>, post flat-field (or open-shutter after acquisition) image, <em>io000001.tif</em>, raw (unprocessed or uncorrected) projections, <em>scan_*.tif</em> (10000 projections in total), <em>data settings XRE.txt</em>, a text file with scanner metadata, <em>script.txt</em> and <em>script_executed.txt</em> are the text files containing the list of commands the apparatus has executed. <strong>Additional Links</strong> These datasets are produced by the Computational Imaging group at Centrum Wiskunde &amp; Informatica (CI-CWI). For any relevant Python/MATLAB scripts for the FleX-ray datasets, we refer the reader to our group's GitHub page. <strong>Contact Details</strong> For more information or guidance in using these dataset, please get in touch with s.b.coban [at] cwi.nl <strong>Acknowledgments</strong> We thank Dr. Samuel McDonald and Prof. Philip Withers for the useful discussion, and Dr. Manuel Dierick for his advice in making this experiment possible.<strong>摘要</strong> 本提交数据集包含药片在水基凝胶中溶解过程的动态断层X射线（dynamic tomographic X-ray）数据。数据采集时长为5分钟，期间样品快速旋转，同时产生泡腾气泡并上浮至凝胶表面。本数据集作为[Coban 2020]中的案例研究3公开发布。 <strong>实验装置</strong> 本数据集由位于阿姆斯特丹CWI（Centrum Wiskunde & Informatica）的TESCAN-XRE公司定制开发的高柔性CT扫描仪FleX-ray Laboratory采集。该装置采用锥束微焦点X射线点光源，将多色X射线投射至1944×1536像素、14位的平面探测器面板上。详细参数可参见[Coban 2020]。 <strong>样品信息</strong> 实验样品为市售假牙清洁片，放置于透明圆柱形塑料容器底部。此类清洁片通常为速溶型，会产生细密紧凑的气泡通道。本次实验选用该类清洁片的原因是其在水中的溶解时长为3~5分钟，气泡产生速率较为平缓。此外，本次实验采用市售水基凝胶替代纯水，以减缓实验过程中气泡的上浮迁移速度。 <strong>实验方案</strong> 本实验在360°范围内采集120幅投影图像，共完成83次旋转，单幅投影曝光时长为30ms。本提交数据集总计包含10000幅投影图像，总采集时长为5分钟。实验期间药片因饱和发生位移，但未完全溶解。空间分辨率为95μm，视场被裁剪至样品架边界（单幅投影图像尺寸为647px×768px）。实验装置可在将凝胶注入样品前采集快门关闭（暗场，dark-field）与快门开启（平场，flat-field）图像。在给定转速下，扫描过程及预实验中均未观察到气泡受到离心力影响。所有原始数据（未经过任何校正处理）均以.tif格式公开。 <strong>内容清单</strong> 本提交数据集的内容如下：<strong>scan</strong>：包含5分钟动态CT数据的文件夹，内含暗场（快门关闭）图像<em>di000000.tif,</em>、采集前平场（快门开启）图像<em>io000000.tif</em>、采集后平场（快门开启）图像<em>io000001.tif</em>、原始（未处理/未校正）投影图像<em>scan_*.tif</em>（总计10000幅）、包含扫描仪元数据的文本文件<em>data settings XRE.txt</em>，以及记录装置执行命令列表的两个文本文件<em>script.txt</em>与<em>script_executed.txt</em>。 <strong>附加链接</strong> 本数据集由阿姆斯特丹数学与计算机科学中心（Centrum Wiskunde & Informatica, CI-CWI）计算成像团队制作。若需获取FleX-ray数据集相关的Python/MATLAB脚本，请查阅本团队的GitHub页面。 <strong>联系方式</strong> 若需获取更多信息或使用本数据集的指导，请联系s.b.coban [at] cwi.nl。 <strong>致谢</strong> 感谢Samuel McDonald博士与Philip Withers教授提供的宝贵讨论，以及Manuel Dierick博士为本次实验的开展提供的建议。