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A Genetic-to-Epigenetic Crosstalk Plays a Pivotal Role in the Promotion of KrasG12D-Induced Senescence and PanIN formation

ChEBI2013-07-01 更新2026-07-21 收录

癌前病变机制

基因-表观遗传交互作用

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-45232 数据链接链接失效反馈

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A Genetic-to-Epigenetic Crosstalk Plays a Pivotal Role in the Promotion of KrasG12D-Induced Senescence and PanIN formation

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创建时间：

2013-07-01

癌前病变机制

肿瘤微环境

Background: Pancreatic ductal adenocarcinomas (PDACs) are highly lethal and aggressive with oncogenic KRAS being the main oncogenic driver of the disease. PDACs have been extensively profiled at advan

NIAID Data Ecosystem40

Single-cell RNA sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium

癌前病变机制

单细胞转录组学

We use single-cell RNA sequencing (scRNA-seq) to explore the transcriptional changes associated with estrogen-induced dysplasia in mouse ovarian surface epithelial cells Overall design: scRNA-seq of c

NIAID Data Ecosystem20

Murine pancreatic acinar cells and high grade PanIN transcriptome.

癌前病变机制

转录组差异分析

Evidence shows that PDAC arises from PanINs: pretumoral lesions originated from transdifferentiation of pancreatic acinar cells. The aim is to increase our understanding of PDAC onset by studying the

NIAID Data Ecosystem10

mRNA expression pattern of KrasG12D mice with acute pancreatitis compared with wild-type mice without acute pancreatitis. Mus musculus

癌前病变机制

转基因小鼠模型转录组学

Transgenic KrasG12D mice can recapitulate pancreas intra-epithelial neoplasia (PanIN). Caerulein is a cholecystokinin analogue and induces acute pancreatitis when injected intra-abdominally. Caerulein

NIAID Data Ecosystem40

ER-phagy and proteostasis defects create a pre-malignant injury state in Kras-mediated tumourigenesis (RNA-Seq)

癌前病变机制

内质网自噬(ER-phagy)

Pancreatic acinar cells are surprisingly resistant to pre-malignant transformation by the mutant Kras oncogene. Here, reporter mice show that an early, transcriptionally-mediated effect of Kras activa

NIAID Data Ecosystem20

A Genetic-to-Epigenetic Crosstalk Plays a Pivotal Role in the Promotion of KrasG12D-Induced Senescence and PanIN formation

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