Single cell transcriptomics delineates the immune-cell landscape in equine lower airways and reveals upregulation of the FKBP5 gene in horses with asthma

In this study, we performed single cell RNA-seq analysis of equine BALF cells in order to study the immune cell landscape of the respiratory tract of horses diagnosed with mild-to-moderate EA (mEA) and healthy controls. Using the Drop-seq method we sequences BALF from eleven horses diagnosed with asthma and eight healthy controls

本研究针对马支气管肺泡灌洗液（bronchoalveolar lavage fluid, BALF）细胞开展单细胞RNA测序（single cell RNA-seq）分析，旨在探究确诊为轻中度EA（mEA）的马匹与健康对照马匹的呼吸道免疫细胞图谱。本研究采用Drop-seq技术，对11匹确诊哮喘的马匹及8匹健康对照马匹的支气管肺泡灌洗液进行测序。