Ribo-seq of iPSC-derived neurons with TDP-43 knockdown. Ribo-seq of iPSC-derived neurons with TDP-43 knockdown

TDP-43 is a key splicing regulator. Here, we perform ribosome profiling on iPSC-derived neurons to examine how translation is affected by TDP-43 knockdown.

TDP-43是关键的剪接调控因子。本研究对诱导多能干细胞（induced pluripotent stem cell, iPSC）衍生神经元开展核糖体谱分析（ribosome profiling），以探究TDP-43敲低对翻译进程的影响。