Prognostic markers in locally advanced lymph node-negative prostate cancer

Age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association between age and disease onset. Carcinogenesis is followed by the deregulation of hundreds of genes, and some of these changes could serve as biomarkers for diagnosis, prognosis, prediction of drug therapy efficacy, as well as possible therapeutic targets. We performed bioinformatic analysis of TCGA data and RNA-Seq transcriptome profiling of a cohort of Russian patients to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (LAPC). We also aimed to identify markers of the most common molecular subtype carrying the fusion transcript TMPRSS2-ERG.年龄是癌症发生的主要风险因素之一。前列腺癌作为一种多因素疾病，其发病率还受人口统计学因素、种族以及遗传易感性的影响。前列腺癌最常发生于60岁以上男性，这表明年龄与疾病发病之间存在明确关联。癌变过程伴随数百个基因的表达失调，其中部分变化可作为诊断、预后、药物治疗疗效预测的生物标志物，同时也可能成为治疗靶点。我们对癌症基因组图谱（TCGA）数据集以及俄罗斯患者队列的RNA测序（RNA-Seq）转录组谱进行了生物信息学分析，以挖掘局部晚期淋巴结阴性前列腺癌（LAPC）的预后标志物。此外，本研究还旨在鉴定携带融合转录本TMPRSS2-ERG的最常见分子亚型的标志物。