Additional file 2 of Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non-tuberculosis mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation

Additional file 2: Supplemental dataset S2. Differentially abundance values of proteins comparing four groups (HC, LTBI, NTM and active TB) to each other’s measured from analyzed in two technical replicates computing the abundances with the MaxLFQ software tool. The analytes were measured from 40 enrolled participants (10 each for the cohorts HC, LTBI, active TB and NTM) from unstimulated and 40 enrolled participants (10 each for the cohorts HC, LTBI, active TB and NTM) from stimulated. Thirty-five proteins were differentially expressed in LTBI comparing to HC, 43 proteins were differentially expressed in NTM comparing to HC and 49 proteins were differentially expressed in active TB comparing to HC, 34 proteins were differentially expressed in NTM as compared to LTBI, 41 proteins were differentially expressed in active TB as compared to LTBI, and 39 proteins were differentially expressed in active TB as compared to NTM in unstimulated plasma samples. In the meanwhile, 50 proteins were differential expressed in LTBI comparing to HC, 41 proteins were differential expressed in NTM comparing to HC, 61 were differentially expressed in active TB comparing to HC, 13 proteins were differentially expressed in NTM as compared to LTBI, 64 proteins were differentially expressed in active TB as compared to LTBI, and 43 proteins were differentially expressed in active TB as compared to NTM. Independent-sample t testing was performed and P-values

附加文件2：补充数据集S2。本数据集包含四组样本（健康对照（Healthy Control, HC）、潜伏结核分枝杆菌感染（Latent Tuberculosis Infection, LTBI）、非结核分枝杆菌感染（Non-Tuberculous Mycobacteria, NTM）与活动性结核病（Active Tuberculosis, active TB））两两比较的蛋白质差异丰度值；所有样本均设置2次技术重复，采用MaxLFQ软件计算蛋白质丰度。本次检测的分析物取自80名入组受试者：其中40名来自未刺激血浆样本队列，另40名来自刺激血浆样本队列；每个队列（HC、LTBI、活动性结核病、NTM）均包含10名受试者。在未刺激血浆样本中，LTBI组与HC组比较有35个差异表达蛋白，NTM组与HC组比较有43个差异表达蛋白，活动性结核病组与HC组比较有49个差异表达蛋白；NTM组与LTBI组比较有34个差异表达蛋白，活动性结核病组与LTBI组比较有41个差异表达蛋白，活动性结核病组与NTM组比较有39个差异表达蛋白。在刺激血浆样本中，LTBI组与HC组比较有50个差异表达蛋白，NTM组与HC组比较有41个差异表达蛋白，活动性结核病组与HC组比较有61个差异表达蛋白；NTM组与LTBI组比较有13个差异表达蛋白，活动性结核病组与LTBI组比较有64个差异表达蛋白，活动性结核病组与NTM组比较有43个差异表达蛋白。本研究采用独立样本t检验进行统计分析，并计算P值。