Pug dog thoracolumbar myelopathy

The datasets consist of genotype data from pug dogs in plink format used for the study Multiple genetic loci associated with pug dog thoracolumbar myelopathy. PDM plink files are QC:ed (--maf 0.01 --geno 0.05 --mind 0.05 and --hwe 1e-10) and relatedness filtered at a threshold of 0.177, including 89 dogs of which 51 were affected by pug dog thoracolumbar myelopathy and 38 were unaffected controls. Genotyping technique is indicated in the FIID column, with GC indicating Gencove low-pass sequenced dogs using Pipeline Dog low pass v2 with 676 dogs in the reference panel and GW indicating genotyped dogs using Illumina 230k CanineHD BeadChip. Chromosomal coordinates are based on the dog CanFam3.1 genome assembly.

本数据集包含用于巴哥犬胸腰椎脊髓病相关多基因位点研究的巴哥犬基因型数据，文件格式为PLINK格式。该PDM格式的PLINK文件已完成质量控制（QC）：采用参数--maf 0.01、--geno 0.05、--mind 0.05及--hwe 1e-10进行质控，并以0.177为阈值过滤亲缘关系样本，最终纳入89只巴哥犬，其中51只为巴哥犬胸腰椎脊髓病患病个体，38只为未患病对照个体。FIID列中标注了基因分型技术信息：GC代表使用Dog low pass v2流程进行低深度测序的Gencove巴哥犬，参考面板包含676只犬；GW代表使用Illumina 230k CanineHD BeadChip进行基因分型的巴哥犬。染色体坐标基于犬类CanFam3.1基因组组装版本。