Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus (Targeted EM-Seq)

To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue and DNA was collected at 0.9 term for targeted EM-Seq analysis Overall design: Comparative fetal baboon (0.9 term) hippocampal targeted EM-Seq analysis from dams with different adiposity and leptin levels为探究母体肥胖与瘦素（leptin）对胎儿脑部发育的影响，本研究于妊娠0.9胎龄时采集胎儿海马脑组织及DNA，用于靶向EM-Seq分析。总体实验设计：针对肥胖程度与瘦素水平存在差异的孕狒狒，对其0.9胎龄的胎儿狒狒海马组织开展靶向EM-Seq对比分析。