Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of Influenza A disease severity

Transcriptional profile in influenza infected patients with different clinical outcomes were investigated. Using gene expression profiling, we investigated the expression level of ~47,000 genes in the whole blood of patients with mild (83 patients), moderate (40 patients) and severe (11 patients) symptoms caused by influenza virus. The gene expression level in these patients was compared with febrile patients caused by unknown pathogens (73 patients)

本研究针对不同临床结局的流感病毒感染患者的转录表达谱（Transcriptional profile）展开探究。我们采用基因表达谱分析（gene expression profiling）技术，对流感病毒感染所致轻症（83例）、中症（40例）及重症（11例）患者的全血样本中约47000个基因的表达水平进行了检测。同时将上述流感感染患者的基因表达水平与不明病原体感染所致发热患者（73例）进行对比分析。