Structure of P. aeruginosa LpxC with compound 12: (2R)-4-(6-(2-Fluoro-4-methoxyphenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Structure of P. aeruginosa LpxC with compound 12: (2R)-4-(6-(2-Fluoro-4-methoxyphenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide Descriptor: (2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide, 1,2-ETHANEDIOL, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... Authors: Surivet, J.-P, Panchaud, P, Specklin, J.-L, Diethelm, S, Blumstein, A.-C, Gauvin, J.-C, Jacob, L, Masse, F, Mathieu, G, Mirre, A, Schmitt, C, Enderlin-Paput, M, Lange, R, Bur, D, Tidten-Luksch, N, Gnerre, C, Seeland, S, Hermann, C, Locher, H.H, Seiler, P, Mac Sweeney, A, Hubschwerlen, C, Ritz, D, Rueedi, G. Deposit date: 2018-11-09 Release date: 2019-12-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.196 Å) Cite: Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria. J.Med.Chem., 63, 2020

铜绿假单胞菌（P. aeruginosa）LpxC与化合物12的共晶结构：(2R)-4-(6-(2-氟-4-甲氧基苯基)-3-氧代-1H-吡咯并[1,2-c]咪唑-2(3H)-基)-N-羟基-2-甲基-2-(甲磺酰基)丁酰胺
描述项：(2R)-4-[6-(2-氟-4-甲氧基苯基)-3-氧代-1H-吡咯并[1,2-c]咪唑-2-基]-2-甲基-2-甲磺酰基-N-羟基丁酰胺、1,2-乙二醇、UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶（UDP-3-O-acyl-N-acetylglucosamine deacetylase）……
作者：Surivet, J.-P、Panchaud, P、Specklin, J.-L、Diethelm, S、Blumstein, A.-C、Gauvin, J.-C、Jacob, L、Masse, F、Mathieu, G、Mirre, A、Schmitt, C、Enderlin-Paput, M、Lange, R、Bur, D、Tidten-Luksch, N、Gnerre, C、Seeland, S、Hermann, C、Locher, H.H、Seiler, P、Mac Sweeney, A、Hubschwerlen, C、Ritz, D、Rueedi, G
沉积日期：2018-11-09
发布日期：2019-12-18
最后修改日期：2024-01-24
实验方法：X射线衍射（2.196 Å）
引用：《发现对革兰氏阴性菌具有强效体外活性的新型LpxC抑制剂》，《药物化学杂志》，2020年，第63卷