Fast DNA Sequencing via Transverse Electronic Transport

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of
a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a
nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with
very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical
implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the
perspective of the genetic makeup of each individual.

一种快速且低成本的脱氧核糖核酸（DNA）测序方法，或将引发医学领域的革命性变革。我们提出了一种基于单链脱氧核糖核酸（single-stranded DNA, ssDNA）穿过纳米孔（nanopore）时产生的横向电流分布的测序方案，并从理论上证明了该方案的可行性。基于这些电流分布的统计特性，我们的估算结果显示，无需并行化处理即可在数小时内以极高精度完成整个人类基因组的测序，其速度比现有技术快数个数量级。该方法的实际落地应用，将极大推动我们从个体遗传构成层面研究、预测并治疗疾病的能力。