Univariable MR estimates for each lipid on total PCa.

Genetically elevated LDL is significantly associated with total PCa only through the IVW approach, whereas the pleiotropy-robust methods do not support this association. Associations of P P ∈ (0.05,0.1], *P ∈ (0.01,0.05], **P ∈ (0.001,0.01], ***P ∈ (0,0.001]. IVW, inverse variance weighting; LDL, low-density lipoprotein; MR, Mendelian randomisation; PCa, prostate cancer. (XLSX)

仅通过逆方差加权（inverse variance weighting, IVW）分析方法，遗传所致低密度脂蛋白（low-density lipoprotein, LDL）水平升高与总体前列腺癌（prostate cancer, PCa）存在显著关联；而多效性稳健分析方法则不支持该关联。关联显著性标注规则如下：P∈(0.05, 0.1]、*P∈(0.01, 0.05]、**P∈(0.001, 0.01]、***P∈(0, 0.001]。其中，IVW指逆方差加权，LDL指低密度脂蛋白，MR指孟德尔随机化，PCa指前列腺癌。本数据集文件格式为XLSX。