Propionibacterium freudenreichii MJ2-derived extracellular vesicles LC-MS/MS

PFEVs inhibit osteoclast differentiation by interfering RANK-RANKL binding, thereby decreasing expression of gene related to osteoclast differentiation and improve CIA, probably through inhibiting inflammation and osteoclastogenesis.

PFEVs通过干扰核因子κB受体活化因子及其配体（RANK-RANKL）的结合，抑制破骨细胞分化，进而下调破骨细胞分化相关基因的表达，从而改善胶原诱导性关节炎（Collagen Induced Arthritis, CIA），其潜在机制可能为抑制炎症反应与破骨细胞生成。