Endotype of Allergic Asthma with Airway Obstruction in Urban Children

In the first decade of life, high-asthma risk urban children develop stable phenotypes of respiratory health versus disease that link early life environmental exposures to childhood allergic sensitization and asthma. Moreover, unique patterns of nasal gene expression demonstrate how specific molecular pathways underlie distinct respiratory phenotypes, including allergic and non-allergic asthma. Overall design: URECA is a high risk asthma birth cohort study. These samples are nasal brush samples taken at age 11. They were used to identify airway gene expression patterns that associate with clinical phenotypes over time.

在生命早期十年中，哮喘高风险城市儿童会形成呼吸道健康与疾病的稳定表型，此类表型可将早期生命环境暴露与儿童过敏性致敏及哮喘建立关联。此外，独特的鼻腔基因表达模式可阐明特定分子通路如何构成过敏性哮喘与非过敏性哮喘等不同呼吸道表型的基础。研究整体设计：URECA是一项哮喘高风险出生队列研究。本次所用样本为受试者11岁时采集的鼻腔刷拭样本，此类样本用于识别随时间推移与临床表型相关的气道基因表达模式。