Supplementary tables of Causal relationship between gut microbiota, blood metabolites, immune cell traits, inflammatory proteins, and cataract: a two-sample, bidirectional mendelian randomization analysis

Table S1: The information of GWAS data for gut microbiota; Table S2: The information of GWAS data for blood metabolites and metabolite ratios; Table S3: The information of GWAS data for immune cell traits; Table S4: The information of GWAS data for circulating inflammatory proteins; Table S5: The results of casual effects and sensitive analysis of identified gut microbiota on cataract; Table S6: The results of casual effects and sensitive analysis of identified blood metabolites and metabolite ratios on cataract; Table S7: The results of casual effects and sensitive analysis of identified immune cell traits on cataract; Table S8: The results of casual effects and sensitive analysis of identified circulating inflammatory proteins on cataract; Table S9: The significant casual effects of two-sample MR analysis in mediation analysis; Table S10: The consistent effect sizes of exposure-outcome, exposure-mediator, and mediator-outcome; Table S11: The results of preliminary MVMR in mediation analysis; Table S12: The results of subsequent MVMR in mediation analysis; Table S13: The results of significant casual effects of cataract on gut microbiota, blood metabolites and metabolite ratios, and circulating inflammatory proteins; Table S14: The genes identified from the causal SNPs using MAGMA; Table S15: The results of functional enrichment analysis of the genes identified from the causal SNPs.

表S1：肠道菌群全基因组关联分析（Genome-Wide Association Study, GWAS）数据信息；表S2：血液代谢物及代谢物比值全基因组关联分析数据信息；表S3：免疫细胞性状全基因组关联分析数据信息；表S4：循环炎症蛋白全基因组关联分析数据信息；表S5：鉴定出的肠道菌群对白内障的因果效应及敏感性分析结果；表S6：鉴定出的血液代谢物及代谢物比值对白内障的因果效应及敏感性分析结果；表S7：鉴定出的免疫细胞性状对白内障的因果效应及敏感性分析结果；表S8：鉴定出的循环炎症蛋白对白内障的因果效应及敏感性分析结果；表S9：中介分析中两样本孟德尔随机化（Mendelian Randomization, MR）分析的显著因果效应；表S10：暴露-结局、暴露-中介物及中介物-结局的一致性效应量；表S11：中介分析中初步多变量孟德尔随机化（Multivariable Mendelian Randomization, MVMR）分析结果；表S12：中介分析中后续多变量孟德尔随机化分析结果；表S13：白内障对肠道菌群、血液代谢物及代谢物比值、循环炎症蛋白的显著因果效应结果；表S14：通过MAGMA工具从因果性单核苷酸多态性（Single Nucleotide Polymorphism, SNP）中鉴定出的基因；表S15：从因果性单核苷酸多态性中鉴定出的基因的功能富集分析结果。