Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity in mice and primates. Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity in mice and primates

Comparison of gene expression profiles after infection with flaviviruses or tratment with toll-like receptor agonists Overall design: Human PBMCs for four individual healthy donors were treated for 48 hours with flaviviruses (dengue viruses and yellow fever) and adjuvants (alum, Pam3CSK4, PolyI:C, LPS, R848 and ODN2006)

黄病毒感染或Toll样受体激动剂（Toll-like receptor agonists）处理后的基因表达谱比较 实验整体设计：选取4名健康个体的外周血单个核细胞（Peripheral Blood Mononuclear Cells, PBMCs），分别用黄病毒（登革病毒与黄热病毒）以及各类佐剂（明矾、Pam3CSK4、PolyI:C、LPS、R848及ODN2006）处理48小时。