Transcriptome sequencing in COPD mice

Chronic obstructive pulmonary disease (COPD), a common respiratory disease, can be divided into stable phase and acute exacerbation phase (AECOPD) and is characterized by inflammation and hyper-immunity. Methylation of N6-methyladenosine (m6A) is an epigenetic modification that regulates the expression and functions of genes by influencing post-transcriptional RNA modifications. Its influence on the immune regulation mechanism has attracted great attention. Herein, we present the m6Amethylomic landscape and observe how the methylation of m6A participates in the pathological process of COPD

慢性阻塞性肺疾病（Chronic obstructive pulmonary disease, COPD）是一种常见呼吸系统疾病，可分为稳定期与急性加重期（acute exacerbation phase, AECOPD），其特征为炎症与免疫亢进。N6-甲基腺嘌呤（N6-methyladenosine, m6A）甲基化是一种表观遗传修饰，可通过影响转录后RNA修饰调控基因的表达与功能，其对免疫调控机制的影响已受到广泛关注。本研究呈现了m6A甲基化组图谱，并揭示了m6A甲基化参与慢性阻塞性肺疾病病理进程的具体方式。