Gene-expression data of (WT) and knock-out (KO) bone marrow derived macrophages (BMDMs) from C57BL/7 mice

We provide gene expression data of wild-type (WT) and various knock-out (KO) bone marrow derived macrophages (BMDMs) from mice (C57BL/6) in different conditions of infections and treatments. We included BMDMs from WT (female and male), Ifnar-/-, IFNg-/-, iNOs-/-, Nlrx1-/- (female and male), Nox2-/- and Prx5-/- mice. BMDMs were either infected with a human protozoan parasite Leishmania guyanensis with or without its endosymbiant double-stranded RNA (dsRNA) virus, Leishmania RNA Virus 1 (LgyLRV1+ and LgyLRV1-, respectively). Alternatively BMDMs were treated with a TLR3 agonist poly I:C, a TLR2 agonist FSL1, with H2O2 or tBHQ. Transcriptomic analysis of WT (female and male), Nlrx1-/- (female and male), Nrf2-/- female, Prx5-/- female and Prx5+/+ (littermate) female BMDMs

本数据集提供了C57BL/6小鼠的野生型（wild-type，WT）及多种基因敲除（knock-out，KO）骨髓源巨噬细胞（bone marrow derived macrophages，BMDMs）在不同感染与处理条件下的基因表达数据。所纳入的BMDMs来源小鼠包括野生型（雌雄兼具）、Ifnar-/-、IFNg-/-、iNOs-/-、Nlrx1-/-（雌雄兼具）、Nox2-/-及Prx5-/-小鼠。BMDMs的干预方案分为两类：其一为感染人源原生动物寄生虫圭亚那利什曼原虫（Leishmania guyanensis），该寄生虫可携带或不携带其内共生双链RNA（dsRNA）病毒——利什曼RNA病毒1型（Leishmania RNA Virus 1，分别记为LgyLRV1+与LgyLRV1-）；其二为分别用Toll样受体3（TLR3）激动剂聚肌胞苷酸（poly I:C）、Toll样受体2（TLR2）激动剂FSL1、过氧化氢（H₂O₂）或叔丁基对苯二酚（tBHQ）进行处理。本研究同时对野生型（雌雄兼具）、Nlrx1-/-（雌雄兼具）、Nrf2-/-雌性、Prx5-/-雌性及Prx5+/+（同窝对照）雌性BMDMs开展了转录组学分析。