Global studies of Nur77 on metabolism of zebrafish

We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique, and then performed the whole-organism RNA sequencing analysis in wild type and nur77-deficient zebrafish to dissect the changes genes in metabolic related pathways.

本研究通过CRISPR/Cas9技术构建了全局Nur77基因敲除斑马鱼模型，随后对野生型及Nur77缺陷型斑马鱼开展全生物体RNA测序分析，以解析代谢相关通路内的基因表达变化。