Risk Factors for Residual Neoplasia After Endoscopic Mucosal Resection

Laterally Spreading Tumors (LST) are important precursosrs of invasive colorectal cancer. Endoscopic treatment has replaced surgery in most of the cases. Nevertheless, after conventional Endoscopic Mucosal Resection (CER), Local Residual Neoplasia (LRN) is an issue. Therefore, endoscopic follow-up and treatment are necessary. To decrease its occurrence, the risk factors of LRN shoudl be identified. Thereafter, in high-risk patients, other modalities of initial treatment including Endoscopic Submucosal Dissection (ESD) and surgical treatment, could be considered. The purpose of this prospective study is to identify risk factors associated with the presence of LRN after CER of LSTs.

侧向发育型肿瘤（Laterally Spreading Tumors, LST）是浸润性结直肠癌的重要前驱病变。内镜治疗已在绝大多数临床病例中替代外科手术。然而，常规内镜黏膜切除术（conventional Endoscopic Mucosal Resection, CER）术后，局部残留肿瘤（Local Residual Neoplasia, LRN）仍是亟待解决的临床难题，因此术后内镜随访与治疗至关重要。为降低LRN的发生率，需明确其发病危险因素。对于高危患者，可考虑采用内镜黏膜下剥离术（Endoscopic Submucosal Dissection, ESD）及外科手术等其他初始治疗手段。本前瞻性研究旨在明确LST患者接受CER术后发生LRN的相关危险因素。