Facile Synthesis of Carbazoles via a Tandem Iodocyclization with 1,2‑Alkyl Migration and Aromatization

A strategy
for the synthesis of iodocarbazoles through a tandem
iodocyclization with migration and aromatization is presented. This
sequential cascade process is concisely conducted at room temperature
and in a short time. Moreover, the obtained halides can be further
applied to palladium-catalyzed coupling reactions, which act as the
important intermediates for building other valuable compounds.

本研究提出了一种通过兼具迁移与芳构化过程的串联碘环化反应合成碘代咔唑的策略。该连续级联反应可在室温下便捷进行，且反应耗时较短。此外，所得卤代产物可进一步应用于钯催化偶联反应，作为构建其他高价值化合物的重要中间体。