extended data(SPIRIT 2013 Checklist).docx

we will study the effect of rehabilitation training based on temporal fine structure on speech in noise perception on patients over the age of 60 years with mild to moderate hearing loss. Age related hearing loss (Presbycusis) is one the most common cause of hearing loss worldwide. It is estimated almost 50% of population more than 75 years old suffer from Presbycusis. Presbycusis mostly characterized by recognition of target speech in noise environment. Sounds are decomposed by the auditory filters to slowly varying envelope (E) and rapid temporal fine structure (TFS). The most important task of TFS is to identify target speech from interfering sounds. Presbycusis highly associated with damage of TFS information. Previous studies indicated the damage of TFS information is permanent but in this study we attempt to prove base on rehabilitation training part of impairment in TFS information will be reestablished

本研究将针对60岁以上轻中度听力损失患者，探究基于时间精细结构（temporal fine structure, TFS）的康复训练对其噪声环境下言语感知能力的影响。
年龄相关性听力损失（Presbycusis，即老年性聋）是全球范围内最常见的听力损失病因之一。据估算，75岁以上人群中约有50%受到老年性聋的困扰。
老年性聋的典型特征为噪声环境下的目标言语识别障碍。声音可经听觉滤波器分解为慢变包络（envelope, E）与快速时间精细结构（TFS），其核心功能是从干扰声源中识别目标言语，且该病症与时间精细结构信息的损伤高度相关。
既往研究表明，时间精细结构信息的损伤是永久性的，但本研究拟通过康复训练验证：部分时间精细结构信息的受损状态可得到恢复。