microRNA profile of human nasopharyngeal tissues: nasopharyngeal carcinoma tissues vs. normal nasopharyngeal tissues

MicroRNAs are biomarkers of prognosis and survival for many types of cancer. We evaluated whether microRNAs can predict the survival and efficacy of concurrent chemotherapy in nasopharyngeal carcinoma (NPC) patients. We retrospectively analyzed microRNA expression in 312 paraffin-embedded NPC specimens and 18 normal nasopharyngeal tissues using microarray. We found Forty-one microRNAs are differentially expressed between NPC and normal tissues, and a five-microRNA signature can predict survival independent of stage. NPC patients with the low-risk microRNA signature have a favorable response to concurrent chemotherapy. microRNA profiling of nasopharyngeal carcinoma tissues vs. normal nasopharyngeal tissues 312 paraffin-embedded nasopharyngeal carcinoma tissues and 18 paraffin-embedded normal nasopharyngeal tissues

微小RNA（microRNA）可作为多种癌症的预后与生存相关生物标志物。本研究旨在探究微小RNA能否预测鼻咽癌（nasopharyngeal carcinoma, NPC）患者的生存情况及同步化疗疗效。研究采用微阵列芯片技术，对312份石蜡包埋的鼻咽癌组织标本与18份正常鼻咽组织中的微小RNA表达水平进行了回顾性分析。结果显示，鼻咽癌组织与正常组织间存在41种差异表达的微小RNA；且一种包含5种微小RNA的特征标签可独立于临床分期预测患者生存情况。携带低风险微小RNA特征标签的鼻咽癌患者，对同步化疗具有更优的应答效果。本数据集涵盖鼻咽癌组织与正常鼻咽组织的微小RNA表达谱，具体包含312份石蜡包埋的鼻咽癌组织标本及18份石蜡包埋的正常鼻咽组织标本。