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Mammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope

ChEBI2025-11-12 更新2026-07-12 收录

DNA损伤修复

染色质生物学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-12712 数据链接链接失效反馈

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资源简介：

Mammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope

应用场景：

创建时间：

2025-11-12

DNA损伤修复

分子机制

Involvement of the synthesis sub-paths in the successful DNA repair in the non-disturbed model.

NIAID Data Ecosystem60

Data and code for analyzing DSB mobility

DNA损伤修复

肌动蛋白动力学

Double-strand breaks (DSBs) are critical lesions in genomic DNA, and their accurate repair is essential for maintaining genome stability. The nuclear actin cytoskeleton has been implicated in homology

DataCite Commons2025-10-22 更新40

Swc4 protects chromatin against genome instability and aneuploidy

染色质生物学

基因组稳定性

In the baker's yeast Saccharomyces cerevisiae, Swc4, Yaf9, Arp4, and Act1 form a submodule shared by histone acetylation NuA4 complex and chromatin remodeling SWR1 complex (SWR1-C). Act1 and Arp4 are

NIAID Data Ecosystem40

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

皮肤癌突变谱

DNA损伤修复

The UV component of sunlight is the major carcinogen involved in the etiology of skin cancers. We have studied the rare, hereditary syndrome xeroderma pigmentosum (XP), which is characterized by a ver

PubMed Central1993-11-15 更新40

Mammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope

资源简介：

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