Supplementary Material for: Cancer-associated retinopathy and optic neuropathy in a patient with lung adenocarcinoma

Paraneoplastic vision loss includes a heterogenous group of ocular disorders that occur in the setting of systemic malignancy. The presenting symptoms are variable, but typically include vision loss that is painless, subacute in onset, and ultimately bilateral. The underlying mechanism is thought to involve molecular mimicry due to structural homology between ocular and cancer antigens. Presentations of paraneoplastic vision loss include cancer-associated retinopathy, paraneoplastic optic neuropathy, paraneoplastic vitelliform maculopathy, bilateral diffuse uveal melanocytic proliferation, melanoma-associated retinopathy, and opsoclonus-myoclonus syndrome. Very few cases have reported simultaneous retinopathy and optic neuropathy. Here we present the case of a 36-year-old female who developed complete vision loss in the right eye, with both retina and optic nerve changes. Extensive investigation revealed a non-mucinous lung adenocarcinoma. We suggest use of the term CARON (Cancer-Associated Retinopathy and Optic Neuropathy) for cases such as these.

副肿瘤性视力丧失（Paraneoplastic vision loss）是一类异质性眼部疾病，继发于全身性恶性肿瘤病程中。其临床表现存在显著异质性，但典型特征为无痛性、亚急性起病、最终双侧受累的视力丧失。目前认为其发病机制与分子模拟相关——即眼部抗原与肿瘤抗原之间存在结构同源性。

副肿瘤性视力丧失的临床表型包括癌症相关性视网膜病变（cancer-associated retinopathy）、副肿瘤性视神经病变（paraneoplastic optic neuropathy）、副肿瘤性卵黄样黄斑病变（paraneoplastic vitelliform maculopathy）、双侧弥漫性葡萄膜黑色素细胞增生症（bilateral diffuse uveal melanocytic proliferation）、黑色素瘤相关性视网膜病变（melanoma-associated retinopathy）以及眼阵挛-肌阵挛综合征（opsoclonus-myoclonus syndrome）。

目前仅见极少数病例报道同时合并视网膜病变与视神经病变。本文报告1例36岁女性患者，其右眼出现完全性视力丧失，同时存在视网膜与视神经病变表现。经全面检查后确诊患者罹患非黏液型肺腺癌。我们建议将此类病例命名为CARON（癌症相关性视网膜病变合并视神经病变，Cancer-Associated Retinopathy and Optic Neuropathy）。