Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia. Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

We report the alteration in H3K4me3 profile in Eµ-TCL1A leukemic splenocytes with or without KDM1A knockdown. Overall design: H3K4me3 ChIP-seq in KDM1A wildtype and KDM1A knockdown Eµ-TCL1A leukemic splenocytes

本研究报道了存在或不存在赖氨酸去甲基化酶1A（KDM1A）基因敲低时，Eµ-TCL1A白血病脾细胞内组蛋白H3赖氨酸4三甲基化（H3K4me3）的谱式改变。整体实验设计：对KDM1A野生型与KDM1A基因敲低的Eµ-TCL1A白血病脾细胞，开展H3K4me3染色质免疫共沉淀测序（ChIP-seq）实验。