Mus musculus domesticus Epigenomics. Mus musculus domesticus

Recent studies have revealed the importance of DNA hypermethylation in the progression of liver fibrosis to hepatocellular carcinoma (HCC). However, the importance of DNA methylation in the early-stage liver fibrosis remains unclear. To address this issue, we used a pathological mouse model of early-stage liver fibrosis that was induced by treatment with carbon tetrachloride (CCl4) for 2 weeks and performed a genome-wide analysis of DNA methylation status.

已有研究表明，DNA高甲基化在肝纤维化进展为肝细胞癌（hepatocellular carcinoma，HCC）的过程中发挥重要作用。然而，DNA甲基化在早期肝纤维化中的作用仍不明确。为解决这一问题，本研究采用了经2周四氯化碳（carbon tetrachloride，CCl4）诱导构建的早期肝纤维化病理小鼠模型，并对其DNA甲基化状态进行了全基因组分析。