Substrate recognition diversity and transport dynamics of ABCC1

The atomic coordinates and cryo-EM density maps have been deposited in the Protein Data Bank (PDB) and Electron Microscopy Data Bank (EMDB) under accession codes PDB: 9LGC and EMDB: EMD-63061 for GSH-vincristine-bound ABCC1, PDB: 9LG8 and EMDB: EMD-63057 for GSH-E1SO4-bound ABCC1, PDB: 9LGA and EMDB: EMD-63059 for GSH-verapamil-bound ABCC1, PDB: 9LGB and EMDB: EMD-63060 for LTC4-bound ABCC1, PDB: 9LG9 and EMDB: EMD-63058 for GSSG-bound ABCC1, PDB: 9LG6 and EMDB: EMD-63055 for 2'3'-CDAS-bound ABCC1, PDB: 9LG7 and EMDB: EMD-63056 for GSH+2'3'-CDAS-bound ABCC1, PDB: 9LGE and EMDB: EMD-63063 for 2-ATP-bound ABCC1 (vincristine), PDB: 9LGF and EMDB: EMD-63064 for 2-ATP-bound ABCC1 (GSH+E1SO4), PDB: 9LGD and EMDB: EMD-63062 for 1-ATP-bound ABCC1.

本数据集的原子坐标与冷冻电镜密度图已提交至蛋白质数据库（Protein Data Bank，PDB）及电子显微镜数据库（Electron Microscopy Data Bank，EMDB），各相关样本的登录码如下：结合谷胱甘肽（glutathione，GSH）-长春新碱（vincristine）的ABCC1蛋白对应登录码PDB: 9LGC、EMDB: EMD-63061；结合谷胱甘肽-E1SO4的ABCC1蛋白对应登录码PDB: 9LG8、EMDB: EMD-63057；结合谷胱甘肽-维拉帕米（verapamil）的ABCC1蛋白对应登录码PDB: 9LGA、EMDB: EMD-63059；结合白三烯C4（leukotriene C4，LTC4）的ABCC1蛋白对应登录码PDB: 9LGB、EMDB: EMD-63060；结合谷胱甘肽二硫化物（glutathione disulfide，GSSG）的ABCC1蛋白对应登录码PDB: 9LG9、EMDB: EMD-63058；结合2'3'-CDAS的ABCC1蛋白对应登录码PDB: 9LG6、EMDB: EMD-63055；结合谷胱甘肽+2'3'-CDAS的ABCC1蛋白对应登录码PDB: 9LG7、EMDB: EMD-63056；结合2-ATP的长春新碱复合物ABCC1蛋白对应登录码PDB: 9LGE、EMDB: EMD-63063；结合2-ATP的谷胱甘肽+E1SO4复合物ABCC1蛋白对应登录码PDB: 9LGF、EMDB: EMD-63064；结合1-ATP的ABCC1蛋白对应登录码PDB: 9LGD、EMDB: EMD-63062。