Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer [scRNA-seq]

We analyzed chromatin accessibility, scATAC-seq and RNA-seq across neuroendocrine carcinomas from distinct anatomic origins including Merkel cell carcinomas, neuroendocrine prostate cancer, small cell lung cancer and gastrointestinal NECs. Overall design: scRNA-seq

我们针对不同解剖起源的神经内分泌癌（neuroendocrine carcinomas, NECs）的染色质可及性（chromatin accessibility）、单细胞转座酶可及性测序（single-cell Assay for Transposase-Accessible Chromatin using sequencing, scATAC-seq）及RNA测序（RNA-seq）进行了分析，所纳入的癌种涵盖默克尔细胞癌、神经内分泌前列腺癌、小细胞肺癌与胃肠道神经内分泌癌。整体实验设计：单细胞RNA测序（scRNA-seq）。