ChIP-seq Leishmania infantum

The study goal was to elucidate the distribution of histone H3 lysine 4 trymethylation (H3K4me3) over the chromatin landscape of Leishmania infantum, the causative agent of canine and human leishmaniasis in the Mediterranean region. To this end, we investigated either the promastigotes (the flagellated motile form) and the amastigotes (the intracellular form) by ChIP-seq.

本研究旨在阐明婴儿利什曼原虫（Leishmania infantum）——地中海地区犬类与人类利什曼病的致病病原体——的全染色质组上的组蛋白H3赖氨酸4三甲基化（histone H3 lysine 4 trimethylation, H3K4me3）分布模式。为此，我们分别针对前鞭毛体（具鞭毛的运动型虫体）与无鞭毛体（胞内寄生型虫体）开展了染色质免疫共沉淀测序（ChIP-seq）实验。