Supplementary Material for: Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review

<b><i>Background:</i></b> Psychiatric genetics has had limited success in translational efforts. A thorough understanding of the present state of translation in this field will be useful in the facilitation and assessment of future translational progress. <b><i>Purpose:</i></b> A narrative literature review was conducted. Combinations of 3 groups of terms were searched in EBSCOhost, Google Scholar, and PubMed. The review occurred in multiple steps, including abstract collection, inclusion/exclusion criteria review, coding, and analysis of included papers. <b><i>Results:</i></b> One hundred and fourteen articles were analyzed for the narrative review. Across those, 4 bottlenecks were noted that, if addressed, may provide insights and help improve and increase translation in the field of psychiatric genetics. These 4 bottlenecks are emphasizing linear translational frameworks, relying on molecular genomic findings, prioritizing certain psychiatric disorders, and publishing more reviews than experiments. <b><i>Conclusions:</i></b> These entwined bottlenecks are examined with one another. Awareness of these bottlenecks can inform stakeholders who work to translate and/or utilize psychiatric genetic information. Potential solutions include utilizing nonlinear translational frameworks as well as a wider array of psychiatric genetic information (e.g., family history and gene-environment interplay) in this area of research, expanding which psychiatric disorders are considered for translation, and when possible, conducting original research. Researchers are urged to consider how their research is translational in the context of the frameworks, genetic information, and psychiatric disorders discussed in this review. At a broader level, these efforts should be supported with translational efforts in funding and policy shifts.

**背景**：精神遗传学（Psychiatric Genetics）的转化研究始终收效有限。全面厘清该领域当前的转化研究现状，有助于推动并评估未来的转化研究进展。**目的**：本研究采用叙述性文献综述（Narrative Literature Review）范式，通过三组检索词组合，在EBSCOhost、Google Scholar及PubMed数据库中开展文献检索。综述流程涵盖多环节：文献摘要收集、纳入/排除标准审核、文献编码以及纳入文献的分析。**结果**：本叙述性综述共纳入114篇文献进行分析。经梳理，该领域的转化研究存在四大瓶颈，若能针对性破解，可为精神遗传学领域的转化研究提供新思路，并助力提升转化效率。这四大瓶颈分别为：过度依赖线性转化框架、仅聚焦分子基因组学研究结果、优先关注特定精神障碍类型，以及综述类文献发表量高于实验类研究。**结论**：本研究对这些相互交织的瓶颈进行了联动剖析。明晰上述瓶颈，可为从事精神遗传学信息转化与应用的利益相关方提供决策参考。潜在优化路径包括：在该研究领域采用非线性转化框架，拓展精神遗传学研究信息的范畴（例如纳入家族史与基因-环境交互作用等维度）；扩大可开展转化研究的精神障碍类型范围；在条件允许的情况下开展原创性实验研究。本研究呼吁研究者结合本文综述中提及的转化框架、遗传信息类型及精神障碍类型，审视自身研究的转化价值。从更宏观的层面而言，此类研究需要获得资金支持与政策调整层面的配套转化研究支持。