Univariate and multivariate Cox analyses of OS in 370 patients with PC not undergoing surgery according to pre-treatment concentrations of plasma YKL-40, IL-6, serum CA 19.9, age, sex and stage.

HR = Hazard ratio. CI = Confidence interval. Stage is scored as IIB+III vs. IV. Hi, high concentration; Lo, low concentration.
Multivariate 1: Dichotomized biomarkers. §Plasma YKL-40 was dichotomized (high vs. normal according to the age-corrected upper 95% percentage limit of YKL-40 in healthy subjects). §§Plasma IL-6 was dichotomized (high vs. normal according to 95% percentage limit of IL-6 in healthy subjects, i.e. cut-off 4.5 ng/l). §§§Serum CA 19.9 was dichotomized (high vs. normal according to the cut-off 37 kU/l).
Multivariate 2: The biomarkers are log transformed (log base 2) i.e. hazards are for a twofold difference.

风险比（Hazard ratio，HR）、置信区间（Confidence interval，CI），其中分期（Stage）的评分标准为IIB+III期与IV期的对比；Hi指代高浓度（high concentration），Lo指代低浓度（low concentration）。
多因素分析1：二分法处理的生物标志物。§ 血浆YKL-40经二分法划分（依据健康人群中经年龄校正的YKL-40的95%百分位上限，分为高浓度与正常浓度组）。§§ 血浆IL-6经二分法划分（依据健康人群中IL-6的95%百分位限值，即截断值4.5 ng/l，分为高浓度与正常浓度组）。§§§ 血清CA 19.9经二分法划分（依据截断值37 kU/l，分为高浓度与正常浓度组）。
多因素分析2：生物标志物经以2为底的对数转换，即此处的风险比对应浓度翻倍时的风险值。