Structural Biology BAG - Portugal

The Portuguese MX BAG includes 13 PIs from three different institutions. Our research interests include soluble and membrane proteins of biomedical interest from humans or pathogenic organisms, many of which can be drug targets. Focus is also given to structural enzymology, aimed at the elucidation of reaction mechanisms, active sites, and inhibition tolerance in proteins with potential biotechnology applications. In several cases, complementary structural biology approaches are being used, combining MX with SAXS and, more recently, CryoEM.

葡萄牙MX BAG包含来自三家不同机构的13名首席研究员（Principal Investigator，PI）。我们的研究方向涵盖人类或病原生物中具有生物医学价值的可溶性与膜蛋白，其中多数可作为药物靶点。研究还聚焦于结构酶学，旨在阐明具有潜在生物技术应用价值的蛋白质的反应机制、活性位点及抑制耐受性。在多个研究案例中，研究人员采用互补性结构生物学方法，将MX与小角X射线散射（SAXS）相结合，且近期更引入了冷冻电子显微镜（CryoEM）技术。