Paris Rive-Gauche BAG: from structure to drug design

Our BAG was created in 2006 to federate well-established structural biology laboratories from south Paris. At present, several projects are investigated by different teams from 5 Institutes: (1) I2BC (Institut de Biologie Inte#grative de la Cellule), (2) IBPC (Institut de Biologie Physico-Chimique), (3) INSERM (Institut National de la Sante# et de la Recherche Me#dicale), (4) LBPA (Laboratoire de Biologie et Pharmacologie Applique#e) and (5) CiTCoM (CiblesTherapeutiques et Conception de Medicaments, ex-name LCRB). Our research area focuses on many important biological systems involved in human pathology or infectious diseases, including molecular chaperones, DNA recombination, RNA maturation, ribosome biogenesis, telomerase assembly, bacterial toxins, malaria disease, neurodegenerative disease, drugs resistance and cell-signalling.

我们的BAG成立于2006年，旨在联合巴黎南部久负盛名的结构生物学实验室。目前，来自5家机构的不同团队正在开展多项研究项目：（1）I2BC（细胞综合生物学研究所）、（2）IBPC（物理化学生物学研究所）、（3）INSERM（法国国家健康与医学研究院）、（4）LBPA（应用生物学与药理学实验室）、（5）CiTCoM（治疗靶点与药物设计实验室，前称LCRB）。我们的研究领域聚焦于人类病理学或传染病相关的多个重要生物系统，包括分子伴侣、DNA重组、RNA成熟、核糖体生物发生、端粒酶组装、细菌毒素、疟疾、神经退行性疾病、耐药性及细胞信号传导。