DataSheet_2_Influence of Magnetic Field Strength on Magnetic Resonance Imaging Radiomics Features in Brain Imaging, an In Vitro and In Vivo Study.pdf

BackgroundThe development and clinical adoption of quantitative imaging biomarkers (radiomics) has established the need for the identification of parameters altering radiomics reproducibility. The aim of this study was to assess the impact of magnetic field strength on magnetic resonance imaging (MRI) radiomics features in neuroradiology clinical practice.
MethodsT1 3D SPGR sequence was acquired on two phantoms and 10 healthy volunteers with two clinical MR devices from the same manufacturer using two different magnetic fields (1.5 and 3T). Phantoms varied in terms of gadolinium concentrations and textural heterogeneity. 27 regions of interest were segmented (phantom: 21, volunteers: 6) using the LIFEX software. 34 features were analyzed.
ResultsIn the phantom dataset, 10 (67%) out of 15 radiomics features were significantly different when measured at 1.5T or 3T (student’s t-test, p < 0.05). Gray levels resampling, and pixel size also influence part of texture features. These findings were validated in healthy volunteers.
ConclusionsAccording to daily used protocols for clinical examinations, radiomic features extracted on 1.5T should not be used interchangeably with 3T when evaluating texture features. Such confounding factor should be adjusted when adapting the results of a study to a different platform, or when designing a multicentric trial.

背景 定量成像生物标志物（放射组学，radiomics）的发展与临床应用，使得识别影响放射组学可重复性的参数成为迫切需求。本研究旨在评估磁场强度对神经放射学临床实践中磁共振成像（MRI）放射组学特征的影响。
方法 采用同一厂商的两台临床磁共振设备，分别以1.5T和3T两种磁场强度，对2个体模与10名健康志愿者采集T1三维SPGR序列。体模的钆浓度与纹理异质性存在差异。使用LIFEX软件对27个感兴趣区进行分割（体模：21个，志愿者：6个），并对34个特征进行了分析。
结果 在体模数据集中，15个放射组学特征中有10个（占比67%）在1.5T与3T下测得的结果存在显著差异（学生t检验，p<0.05）。灰度重采样与像素尺寸同样会对部分纹理特征产生影响。上述结论在健康志愿者队列中得到了验证。
结论 按照临床检查的日常操作规范，在评估纹理特征时，1.5T与3T设备提取的放射组学特征不可互换使用。当将某一研究的结果适配至不同设备平台，或开展多中心试验时，应当对这类混杂因素进行校正。