Annotated sequence of gH-scFv chimera in R-VG803 and R-VG809.
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https://figshare.com/articles/dataset/_The_Engineering_of_a_Novel_Ligand_in_gH_Confers_to_HSV_an_Expanded_Tropism_Independent_of_gD_Activation_by_Its_Receptors_/1422303
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资源简介：
Regions of interest are highlighted as follows. Signal sequence, yellow. scFv to HER2, blue. Upstream and downstream Ser-Gly linkers, green. scFv intermediate linker, red. Two residues implicated in MAb 52S epitope, S536 and A537 in wt-gH, fuchsia.
(PDF)
目标区域的高亮标注方式如下：信号肽序列以黄色高亮；靶向人表皮生长因子受体2（Human Epidermal Growth Factor Receptor 2, HER2）的单链抗体可变区片段（single chain fragment variable, scFv）以蓝色高亮；上下游丝氨酸-甘氨酸接头以绿色高亮；scFv中间接头以红色高亮；野生型gH（wild-type gH, wt-gH）中与单克隆抗体（monoclonal antibody, MAb）52S表位相关的两个残基S536与A537以紫红色高亮。
（PDF）
创建时间：
2015-05-21
