Differentially expressed genes and pathways in SARS-CoV-2 specific memory B cells across disease severity at single cell resolution

This <i>dataset</i> was generated as a part of a study where we looked at the gene signatures and pathways in RBD-specific memory B cells across disease severity in SARS-CoV-2 infected individuals at convalacense. We identified that certain activated memory B cell signatures that were maintained over a period of 6 months in severe infected individuals, whereas declined in mild/moderate over time.

本数据集源自一项研究，该研究针对恢复期严重急性呼吸综合征冠状病毒2型（Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2）感染者体内、按疾病严重程度分层的受体结合域（Receptor Binding Domain, RBD）特异性记忆B细胞中的基因特征与信号通路展开分析。研究团队发现，部分活化记忆B细胞特征在重症感染者体内可维持长达6个月，而在轻症/中度感染者体内则随时间推移逐渐衰减。