Supplementary Data S2 - DESeq2 result tables of all datasets analyzed along with flag columns for each of the 8 GO terms used throughout the manuscript. Metadata on the GO terms is included in the sheet "GO_metadata".

Supplementary Data S2 of the manuscript "<b>Hypoxia leads to reduced mito-nuclear gene expression and to increased mtDNA transcriptional pausing in human cells</b>" by Shtolz et al.<br>sheet name - <b>results: </b>DESeq2 "result" output. Main columns:<b>Name:</b> gene symbol<b>baseMean</b>: Mean normalized expression across all samples<b>log2FoldChange</b>: log₂ fold-change between treatment (hypoxia) and control (normoxia).<b>lfcSE</b>: Standard error of the log₂fold-change<b>stat</b>: Negative binomial test statistic.<b>p-value</b><b>padj:</b> Benjamin-Hodgkin-adjusted p-value<b>dataset</b>: Name of the dataset<b>cell line</b><b>Complex</b>: Complex association of gene (either complex I, II, III, IV and V of OXPHOS or the mito-ribosome)<b>Genome</b>: Genome of the gene (NUC for nucleus or MT for mitochondrial DNA, applied only to OXPHOS or mito-ribosome genes).<b>ensembl.gene</b>: Ensemble gene ID.<b>GO_000x: </b>8 columns, binary columns, one for each of the 8 GO terms used in the manuscript.sheet name - <b>GO_metadata</b>: contains information on each of the GO terms used in the manuscript and as columns in the "results" sheet.Data used to generate Figures 1, 2, 3a-c, 4a, 4b and 4e, and Supplementary Figures S1, S2, S5, S6 and S7.

本数据集为Shtolz等人发表的论文《缺氧导致人类细胞线粒体-核基因表达降低及线粒体DNA（mitochondrial DNA，mtDNA）转录暂停增加》的补充数据S2。其工作表名为**结果（results）**，内容为DESeq2软件的"result"输出结果，主要列项如下：
- **Name**：基因符号（gene symbol）
- **baseMean**：所有样本的归一化平均表达量
- **log2FoldChange**：处理组（缺氧）与对照组（常氧）间的log₂倍变化值
- **lfcSE**：log₂倍变化值的标准误
- **stat**：负二项检验统计量
- **p-value**：P值
- **padj**：本杰明-霍奇金（Benjamin-Hodgkin）校正后的P值
- **dataset**：数据集名称
- **cell line**：细胞系
- **Complex**：基因的复合物关联类型，涵盖氧化磷酸化（OXPHOS）复合物I、II、III、IV、V，以及线粒体核糖体（mito-ribosome）
- **Genome**：基因所在基因组，其中NUC代表核基因组，MT代表线粒体DNA基因组，该列仅适用于氧化磷酸化或线粒体核糖体基因
- **ensembl.gene**：Ensembl基因ID（Ensembl gene ID）
- **GO_000x**：共8列二元列，对应论文中使用的8个基因本体（Gene Ontology，GO）术语。

名为**GO_metadata**的工作表包含论文中使用的、同时作为"结果"工作表列项的各GO术语的相关信息。

本数据集可用于生成图1、图2、图3a-c、图4a、图4b及图4e，以及补充图S1、S2、S5、S6和S7。