Supplementary Material for: Poroid hidradenoma: case report and comprehensive review of the literature

Poroid hidradenoma (PH) is a rare benign adnexal tumor of eccrine differentiation. It is the rarest of the four described variants of poroid neoplasms. PHs characteristically share a hybrid of the architectural features of the hidradenoma, namely tumor cells are entirely intradermal with both solid and cystic components, and the cytologic characteristics of the poroid neoplasms, containing predominantly poroid and cuticular cells. Many published reports of PH since its original discovery in 1990 state that “very few” cases of PH can be found in the literature. Here we have identified a total of 75 published accounts of PH, including the case presented here, as well as the associated patient demographics, lesion characteristics, treatment, and outcomes. We suggest that while uncommon, PH is likely not exceptionally rare and could be an underreported diagnosis.

孔状汗腺瘤（Poroid hidradenoma, PH）是一类罕见的、具有外分泌分化的良性皮肤附属器肿瘤，亦是四种已被报道的孔状肿瘤亚型中最为罕见的一种。PH的典型特征兼具汗腺瘤的组织结构特点与孔状肿瘤的细胞学特征：肿瘤细胞完全位于真皮内，同时包含实性与囊性两种成分，且肿瘤细胞以孔状细胞及角质细胞为主。自1990年PH首次被发现以来，诸多已发表的研究均提及“文献中记载的PH病例极少”。本研究共搜集到75篇已发表的PH相关文献报道（含本文所报告的病例），并涵盖了相关患者的人口统计学特征、病变特点、治疗方案及转归情况。我们认为，PH虽不常见，但可能并非极度罕见，其大概率属于一类报道不足的诊断病例。