Genetic Model for Oral Cancer. Mus musculus

Dr. Ravindra Uppaluri, a head and neck surgeon at Washington University, has developed a cell line model of mouse oral squamous cell carcinomas (OSCC) for genetic research. Using these tumors and microarry, his lab identified a molecular signature of metastasis that correlates well with human tumors displaying metastasis. This project contains the exome sequence from those cell lines: 3 indolent tumors and 2 aggressive tumors. This is one of several projects at The Genome Institute to characterize mouse models of human cancer.

华盛顿大学头颈外科医师拉温德拉·厄帕卢里（Ravindra Uppaluri）博士开发了一种用于遗传学研究的小鼠口腔鳞状细胞癌（oral squamous cell carcinomas, OSCC）细胞系模型。其研究团队利用该肿瘤模型与微阵列（microarray）技术，鉴定出了与发生转移的人类肿瘤高度相关的转移分子特征。本项目包含上述细胞系的外显子组测序数据，涉及3株惰性肿瘤细胞系与2株侵袭性肿瘤细胞系。该项目是基因组研究所（The Genome Institute）开展的人类癌症小鼠模型表征系列研究项目之一。