An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis

The primary objective is to evaluate the long-term safety and tolerability of BIIB078 in participants with chromosome 9 open reading frame 72-amyotrophic lateral sclerosis (C9ORF72-ALS).The secondary objective is to evaluate the pharmacokinectic (PK) of BIIB078 in participants with C9ORF72-ALS.

本研究的主要目标为评估BIIB078在9号染色体开放阅读框72相关肌萎缩侧索硬化症（C9ORF72-ALS）受试者中的长期安全性与耐受性。次要目标为评估BIIB078在C9ORF72-ALS受试者中的药代动力学（PK）特征。