Sparfloxacin: effects on arterial blood pressure, heart rate and electrocardiographic parameters, following oral administration in the conscious beagle dog monitored by telemetry

n=3 males and 3 females chronically-instrumented conscious Beagle dog using telemetry. Animals were dosed with sparfloxacin at 30 and 10 mg/kg po, successively (wash-out of 1 week). No PK phase. Parameters: haemodynamic parameters (SAP, DAP, MAP, HR) and ECG (RR, PR, QRS, QT, QTcF and QTcVdW intervals), body temperature. Timepoints: bBefore treatment: -1.5, -1 and -0.5 hours ; after treatment: 0.5, 1, 2, 3, 4, 6, 7 and 24 hours.

本数据集以6只经慢性植入式遥测装置的清醒比格犬（Beagle dog）为实验对象，其中雄性、雌性各3只。实验动物先后以30 mg/kg、10 mg/kg的剂量口服给予司帕沙星（sparfloxacin），两次给药间隔1周洗脱期。本数据集无药代动力学（PK）阶段。观测参数涵盖血流动力学指标：收缩动脉压（Systolic Arterial Pressure, SAP）、舒张压（Diastolic Arterial Pressure, DAP）、平均动脉压（Mean Arterial Pressure, MAP）与心率（Heart Rate, HR）；心电图（Electrocardiogram, ECG）指标：RR、PR、QRS、QT、QTcF及QTcVdW间期；以及体温。采样时间点设置为：给药前为-1.5、-1及-0.5小时，给药后为0.5、1、2、3、4、6、7及24小时。