Table_1_Association between triglyceride glucose index and risk of cancer: A meta-analysis.docx

BackgroundTriglyceride glucose (TyG) index as a more convenient and reliable predictor of insulin resistance (IR) is thought to be associated with many diseases, but its relationship with cancer remains unclear.
MethodsThe meta-analysis was conducted to evaluate the effects of TyG index on cancer risk utilizing the available evidence. PubMed, EMBASE, Medline, Cochrane Library and Web of Science were searched from their inception up to July 2022. A random-effects model was used to calculate the effect estimates and 95% confidence intervals (CIs).
ResultsA total of 6 observational studies met our inclusion criteria, which including 992292 participants. The meta-analysis indicated that the higher TyG index increased cancer risk compared to the lower TyG index group (total effect size =1.14, 95% CI [1.08, 1.20], P<0.001).
ConclusionsOur meta-analysis found that higher TyG index may increase the risk of cancer. More prospective cohort studies and basic research are warranted to verify the relationship.

背景 甘油三酯-葡萄糖（Triglyceride glucose, TyG）指数作为一种更为便捷可靠的胰岛素抵抗（insulin resistance, IR）预测指标，被认为与多种疾病存在关联，但其与癌症的相关性仍未明确。
方法 本荟萃分析（meta-analysis）旨在利用现有研究证据，评估TyG指数对癌症风险的影响。研究检索了PubMed、EMBASE、Medline、Cochrane图书馆及Web of Science自建库至2022年7月的相关文献。采用随机效应模型计算效应量与95%置信区间（confidence intervals, CIs）。
结果 共计6项符合纳入标准的观察性研究被纳入本次分析，累计纳入992292名受试者。荟萃分析结果显示，相较于低TyG指数组，高TyG指数组的癌症风险显著升高（合并效应量=1.14，95%CI [1.08, 1.20]，P<0.001）。
结论 本次荟萃分析发现，较高的TyG指数可能升高癌症发病风险。未来需开展更多前瞻性队列研究与基础研究，以验证二者之间的关联。