Additional file 1 of Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study

Additional file 1: Table S1. STROBE-MR Checklist; Table S2. Key characteristics of participating studies; Table S3. GWAS significant SNPs used as genetic instruments for VD level on PCOS; Table S4. GWAS significant SNPs used as genetic instruments for PCOS on VD level; Table S5. GWAS significant SNPs used as genetic instruments for VD level on BT; Table S6. GWAS significant SNPs used as genetic instruments for BT on PCOS; Table S7. GWAS significant SNPs used as genetic instruments for BT and VD level on PCOS; Table S8. Heterogeneity and directional pleiotropy test using MR-Egger intercepts; Table S9. Potentially relevant genes corresponding to IVs associated with VD and PCOS; Table S10. Potentially relevant genes corresponding to IVs associated with VD and PCOS; Table S11. GO and KEGG enrichment analysis for potentially relevant genes related to VD and PCOS; Table S12. GO and KEGG enrichment analysis for potentially relevant genes related to VD and BT; Figure S1. Scatter plot of the MR estimates for the association of VD level with PCOS; Figure S2. Funnel plot reveals overall heterogeneity of the impact of VD on PCOS; Figure S3. Leave-one-out analysis of the impact of the VD on PCOS.

附加文件1：表S1. STROBE-MR核查清单；表S2. 纳入研究的关键特征；表S3. 用作维生素D（VD）水平对多囊卵巢综合征（PCOS）关联分析的遗传工具的全基因组关联研究（GWAS）显著单核苷酸多态性（SNPs）；表S4. 用作多囊卵巢综合征（PCOS）对维生素D（VD）水平关联分析的遗传工具的全基因组关联研究（GWAS）显著单核苷酸多态性（SNPs）；表S5. 用作维生素D（VD）水平对BT关联分析的遗传工具的全基因组关联研究（GWAS）显著单核苷酸多态性（SNPs）；表S6. 用作BT对多囊卵巢综合征（PCOS）关联分析的遗传工具的全基因组关联研究（GWAS）显著单核苷酸多态性（SNPs）；表S7. 用作BT与维生素D（VD）水平对多囊卵巢综合征（PCOS）关联分析的遗传工具的全基因组关联研究（GWAS）显著单核苷酸多态性（SNPs）；表S8. 采用孟德尔随机化-埃格特（MR-Egger）截距进行的异质性与方向性多效性检验；表S9. 与维生素D（VD）和多囊卵巢综合征（PCOS）相关的工具变量（IVs）对应的潜在关联基因；表S10. 与维生素D（VD）和多囊卵巢综合征（PCOS）相关的工具变量（IVs）对应的潜在关联基因；表S11. 与维生素D（VD）和多囊卵巢综合征（PCOS）相关的潜在关联基因的基因本体（GO）与京都基因与基因组百科全书（KEGG）富集分析；表S12. 与维生素D（VD）和BT相关的潜在关联基因的基因本体（GO）与京都基因与基因组百科全书（KEGG）富集分析；图S1. 维生素D（VD）水平与多囊卵巢综合征（PCOS）关联的孟德尔随机化（MR）估计散点图；图S2. 漏斗图揭示维生素D（VD）对多囊卵巢综合征（PCOS）影响的整体异质性；图S3. 维生素D（VD）对多囊卵巢综合征（PCOS）影响的留一法分析