脂肪酸代谢的蛋白质组学数据
收藏中国科学院兰州化学物理研究所科学数据中心2026-01-15 更新2026-01-17 收录
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https://ggjsfwdata.licp.cn/dataDetails/a41105cc0a324444a89957ed7a69e86a
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资源简介：
这是代谢关键酶乙酰辅酶A羧化酶1（ACC1）作为可转移信号载体，通过外泌体介导细胞间通讯，从而驱动肿瘤耐药表型跨细胞传播过程的蛋白质组学数据。它完整解析了从耐药细胞“主动输出”完整功能酶，到敏感细胞“接收内化”并直接重编程自身脂肪酸代谢，最终在群体层面获得耐药能力的全新跨尺度调控路径。
This is a proteomics dataset focusing on the key metabolic enzyme Acetyl-CoA carboxylase 1 (ACC1) acting as a transferable signaling carrier. It mediates exosome-dependent intercellular communication to drive the intercellular transmission of the tumor drug-resistant phenotype, and fully elucidates a novel cross-scale regulatory pathway spanning from the active export of fully functional ACC1 by drug-resistant cells, to the uptake and internalization by drug-sensitive cells that directly reprogram their endogenous fatty acid metabolism, and ultimately culminating in the acquisition of drug-resistant capacity at the cellular population level.
提供机构：
中国科学院兰州化学物理研究所科学数据中心
创建时间：
2026-01-15
