Single-Cell Multiome Impact of Prenatal Heavy Metal Exposure on Early Airway Development

This dataset includes data from a study on prenatal cadmium (Cd) and arsenic (As) exposure effects on fetal lung development in mice exposed at embryonic stage E12. The files are organized into chromatin accessibility and gene expression matrices. Chromatin accessibility data is stored in atac_fragments_control.tsv.gz and atac_fragments_treated.tsv.gz for control and treated groups, respectively; each line represents a unique ATAC-seq fragment, which can be indexed using .tbi files (atac_fragments_control.tsv.gz.tbi and atac_fragments_treated.tsv.gz.tbi). These fragments files capture accessible chromatin regions. The gene expression matrices are contained in filtered_feature_bc_matrix_control.h5 for control and filtered_feature_bc_matrix_treated.h5 for treated samples, representing gene and peak feature counts per barcode, identifying cell-type-specific expression changes. These data types collectively provide a detailed view of chromatin accessibility and gene expression responses to toxic metal exposure.

该数据集包含一项关于胚胎期E12暴露的小鼠中，产前镉（Cd）和砷（As）暴露对胎儿肺发育影响的研究数据。文件被组织为染色质可及性矩阵和基因表达矩阵。染色质可及性数据分别存储在对照组的atac_fragments_control.tsv.gz和处理组的atac_fragments_treated.tsv.gz中；每行代表一个独特的ATAC-seq片段，可通过.tbi文件（atac_fragments_control.tsv.gz.tbi和atac_fragments_treated.tsv.gz.tbi）进行索引。这些片段文件记录了染色质可及区域。基因表达矩阵包含在对照组的filtered_feature_bc_matrix_control.h5和处理组的filtered_feature_bc_matrix_treated.h5中，代表每个条形码的基因和峰特征计数，可用于识别细胞类型特异性表达变化。这些数据类型共同提供了染色质可及性和基因表达对有毒金属暴露响应的详细视图。