Interaction between dental biofilm microbiome and gingival model. human oral metagenome

our purpose of this study is to perform analysis about both of host model (RHG) and experimental biofilm formed with the use of in situ dental biofilm model. The novelty of our study is to perform analysis of dental biofilm, which has never performed, and the experimental biofilm has microbiome and structure similar to dental biofilm in oral cavity and the hypothesis is that in situ dental biofilm can be affected by host gingiva model.

本研究旨在同时针对宿主模型（RHG）以及采用原位牙菌斑生物膜模型（in situ dental biofilm model）制备的实验性生物膜（biofilm）开展分析。本研究的创新点在于开展了此前从未有人进行过的牙菌斑生物膜（dental biofilm）相关分析；所制备的实验性生物膜其微生物组（microbiome）与结构均与口腔内天然牙菌斑生物膜高度相似，且本研究提出的假说为：原位牙菌斑生物膜可受到宿主牙龈模型（host gingiva model）的影响。