Additional file 1 of Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Additional file 1: Table S1. Genetic variants used to instrument BMI, WHR and metabolites. Table S2. Assesment of instrument strength. Table S3. Colorectal cancer case distributions by study, sex and site. Table S4. LogOR colorectal cancer per SD higher BMI or WHR. Table S5. Beta change in NMR-detected metabolite per SD higher BMI or WHR. Table S6. LogOR colorectal cancer per SD higher BMI or WHR-driven NMR-detected metabolite. Table S7. Risk of overall colorectal cancer per SD higher adipose or metabolite trait, estimated using multivariable Mendelian randomization. Table S8. Posthoc investigations.

附加文件1：表S1。用作身体质量指数（BMI, Body Mass Index）、腰臀比（WHR, Waist-to-Hip Ratio）及代谢物工具变量的遗传变异体。表S2：工具变量强度评估。表S3：按研究、性别与发病部位划分的结直肠癌病例分布情况。表S4：每升高1个标准差的BMI或WHR对应的结直肠癌对数比值比（LogOR）。表S5：每升高1个标准差的BMI或WHR对应的核磁共振（NMR, Nuclear Magnetic Resonance）检测代谢物的β变化值。表S6：每升高1个标准差的BMI或WHR驱动的核磁共振（NMR）检测代谢物对应的结直肠癌对数比值比。表S7：使用多变量孟德尔随机化（multivariable Mendelian randomization）法估算的每升高1个标准差的脂肪组织或代谢物特征对应的总体结直肠癌发病风险。表S8：事后分析。